Research
In Khaperskyy lab, we study virus-host interactions and cellular stress responses.
Our goal is to understand how cells respond to virus infection and other stresses and to identify molecular pathways that can be targeted for antiviral therapies and cancer treatments.
Main research themes in the lab are:
Host shutoff
To gain preferential access to the protein synthesis machinery and to disrupt induction of antiviral responses by infected cell many viruses block host gene expression. This blockade is called host shutoff and it is mediated by viral factors that either destroy host messenger RNAs (mRNAs) or interfere with their synthesis. Influenza A virus (IAV) and… Continue reading Host shutoff
Stress Granules
Stress granules (SGs) are cytoplasmic foci of RNA and proteins that form in cells under stress. Several research projects in the laboratory study properties and functions of these granules. SGs are best detected via microscopy using immunofluorescence (IF) staining for SG proteins or fluorescence in situ hybridization (FISH) of RNAs. In our laboratory we do… Continue reading Stress Granules
Molecular and Cellular Virology Lab 