Khaperskyy lab

We study virus-host interactions with a focus on intrinsic cell defense mechanisms and their subversion by influenza viruses and coronaviruses. Another area of interest in the lab is the biology of stress granules – cytoplasmic foci of messenger RNA-protein complexes that form in response to various types of stress.

News and announcements:

1 January 2022
Our laboratory turns 3 years old! We officially started in January 2019 with one research assistant and two undergraduate students. Including the PI, we are entering 2022 with 9 members! Like many virology labs we also extended our research focus to include coronaviruses. Having grown and matured, we are looking forward to new discoveries and great science!

24 March 2021
Thiopurines Activate an Antiviral Unfolded Protein Response That Blocks Influenza A Virus Glycoprotein Accumulation is out in the Journal of Virology! This paper is a product of long-time collaboration with Michel Roberge (UBC) and Craig McCormick (Dalhousie) laboratories on the search for host-directed antivirals that potentiate cellular stress responses!

3 March 2021
Our projects focused on mechanisms of viral host shutoff receive Canadian Institutes of Health Research (CIHR) funding in Fall 2020 Project Grant competition!!! We are very grateful to the reviewers, the VVP panel, and the CIHR for recognizing our work!

10 December 2020
Khaperskyy lab receives New Health Investigator Grant from Research Nova Scotia. This award will help fund our studies on the Role of stress granule formation in immune responses to respiratory viruses for the next 2 years! We are very grateful to Research Nova Scotia for this funding specifically designated for early career investigators!

1 October 2020
UV damage induces G3BP1-dependent stress granule formation that is not driven by translation arrest via mTOR inhibition.
First Khaperskyy lab independent paper is out at Journal of Cell Science! First in what hopefully will be a series of studies of UV-induced SGs.

23 July, 2020
Selective Degradation of Host RNA Polymerase II Transcripts by Influenza A Virus PA-X Host Shutoff Protein
is cited 42 times and ranks within top 10% most cited PLoS Pathogens papers published in 2016!!!

8 April 2020
Fine-tuning a blunt tool: Regulaton of viral host shutoff RNases. Daly et al., 2020. PLoS Pearl minireview is out! Another collaborative work with Gaglia lab

12 August 2019
Our lab receives infrastructure funding from CFI John R. Evans Leaders Fund (JELF)! As part of the $61 million investment in science projects across Canada, our award will fund state-of-the-art equipment that will boost research capacity in our lab and will be used by other Dal researchers as well!

22 April 2019
It’s great news: we received NSERC Discovery Grant that will support our research on stress granules for the next 5 years!!!

16 April 2019
Our collaborative Cell Reports paper with McCormick and Gaglia labs is out today!
The influenza A virus endoribonuclease PA-X usurps host mRNA processing machinery to limit host gene expression. Gaucherand et al., 2019