We study virus-host interactions with a focus on intrinsic cell defense mechanisms and their subversion by influenza viruses. Another area of interest in the lab is the biology of stress granules – cytoplasmic foci of messenger RNA-protein complexes that form in response to various types of stress.
News and announcements:
1 October 2020
UV damage induces G3BP1-dependent stress granule formation that is not driven by translation arrest via mTOR inhibition. First Khaperskyy lab independent paper is out at Journal of Cell Science! First in what hopefully will be a series of studies of UV-induced SGs.
23 July, 2020
Selective Degradation of Host RNA Polymerase II Transcripts by Influenza A Virus PA-X Host Shutoff Protein is cited 42 times and ranks within top 10% most cited PLoS Pathogens papers published in 2016!!!
8 April 2020
Fine-tuning a blunt tool: Regulaton of viral host shutoff RNases. Daly et al., 2020.
Our PLoS Pearl minireview is out!
Another collaborative work with Gaglia lab
12 August 2019
Our lab receives infrastructure funding from CFI John R. Evans Leaders Fund (JELF)! As part of the $61 million investment in science projects across Canada, our award will fund state-of-the-art equipment that will boost research capacity in our lab and will be used by other Dal researchers as well!
16 April 2019
Our collaborative Cell Reports paper with McCormick and Gaglia labs is out today!
The influenza A virus endoribonuclease PA-X usurps host mRNA processing machinery to limit host gene expression. Gaucherand et al., 2019