Khaperskyy lab

14-17 July 2025
Jack Case presented his research on baloxavir resistance mutations in influenza A virus at the American Society for Virology (ASV) Meeting in Montreal, QC. The meeting also featured a sattelite symposium of the Canadian Society for Virology.

17 February 2025
Juliette’s review Innate immune evasion and general host shutoff strategies of human respiratory RNA viruses is published in Future Virology. In this article we argue that while many viruses encode multiple and often redundant mechanisms of innate immune suppression, potent general host shutoff is characteristic of viruses with wider host range and greater ability to cause reinfections.

15 November 2024
Our team receives 1-year CIHR Catalyst Grant funding for avian influenza research. The project is focused on functional characterization of cross-reactive and specific antibodies against highly pathogenic avian influenza at human/wildlife interface (co-applicants Drs. Lisa Barrett and Craig McCormick, Dalhousie University, Lisanework Ayalew, University of Prince Edward Island, and Andrew Lang, Memorial University of Newfoundland).

2-5 June 2024
Caleb Galbraith, Jack Case, and Juliette Bougon presented their research at the Canadian Society for Virology Meeting in Saskatoon, SK. Everyone did excellent job and represented our lab well. To top it all, Juliette got an award for best talk!

17 April 2024
Eileigh’s and Juliette’s paper on interplay between NS1 and PA-X in influenza A virus host shutoff is out in Journal of Virology: Influenza A virus NS1 effector domain is required for PA-X-mediated host shutoff in infected cells. Awesome collaboration with John Archibald Laboratory for Genome Biology! Juliette presented this work at the 2024 Infectious Disease Research Day in Halifax, NS.

31 January 2024
Another first author paper for Stacia Dolliver is out in Viruses: Human Betacoronavirus OC43 Interferes with the Integrated Stress Response Pathway in Infected Cells. Congratulations to Stacia and Caleb Galbraith who also contributed to this work!

9-11 October 2023
Valeriia Spirina presented her PhD research on UV-induced SGs at the RNA Granules 2023 conference that took place in De Vere Horsley Estate, Surrey, UK. This conference series was started in 2014 here in Halifax and since the interest in biomolecular condensates is steadily growing. Big thanks to Biochemical Society for awarding Valeriia a bursary to attend this meeting!

24-28 June 2023
Juliette Bougon and Stacia Dolliver presented their influenza A virus and the common cold coronavirus OC43 research at the American Society for Virology meeting in Athens, Georgia, USA. ASV conferences are large annual meetings of virologists from around the world and our lab was well represented!

19 December 2022
Stacia’s MSc thesis work is out in PLoS Pathogens: Nsp1 proteins of human coronaviruses HCoV-OC43 and SARS-CoV2 inhibit stress granule formation. What a nice way to finish the year! Another paper produced in collaboration with the Corcoran Lab (University of Calgary). In this work we show that viral host shutoff factors are important contributors to stress granule suppression in Coronavirus infected cells, the link that was previously demonstrated for influenza A virus host shutoff.

6 October 2022
Another MSc student graduates from our lab today! Eileigh Kadijk defends her MSc thesis “Functional interplay of influenza A virus NS1 and PA-X proteins mediates host shutoff“. Congratulations Eileigh!

26 July 2022
Today Stacia Dolliver defended her MSc thesis “Characterizing the modulation of stress granule responses by coronaviruses” and became the first graduate student graduating from our laboratory! Congratulations Stacia! You set the bar high!

5-7 June 2022
Eileigh Kadijk, Stacia Dolliver, and Shan Ying presented their research at the Canadian Society for Virology Meeting in Edmonton, AB. We are very grateful to CSV for providing travel awards for all trainees! Our entire lab attended the meeting, which was not only the first post-pandemic in person conference for our group, but also the very first scientific conference for our trainees!